The first thing is to change your app's web.config to specify the following section. This should be in a level within the
...
proxyaddress="http://YourISAServer:YourPort"
bypassonlocal="true"
/>
...
Once this has been done, you need to tell your Network Admins to setup a rule for allowing your application to pass through the ISA to outside resource. You can either supply them with the URLs of the outside resource or they can monitor the ISA server to see what is being denied. Once the ISA server is configured with the appropriate rules, then you should back in business.